No seminar as many people will be at the Young Researchers Symposium in Hamburg, 19.-21.11.25

Guest talk by Marcin Tabaka (ICTER)

International Centre for Translational Eye Research

Institute of Physical Chemistry, PAS

https://tabaka-lab.org/

Single-cell sequencing methods to resolve biological processes in health and disease

Recent advances in single-cell sequencing have transformed our ability to study cellular diversity, developmental trajectories, and gene regulatory mechanisms at unprecedented resolution. The emergence of uni- and multimodal single-cell technologies now enables simultaneous measurement of multiple molecular layers, such as gene expression, chromatin accessibility, and protein abundance within the same cell. These approaches provide a powerful framework for dissecting the complex interplay of regulatory processes that shape cell states and transitions in health and disease. However, analyzing such high-dimensional multimodal datasets presents substantial computational challenges, requiring integrative models that jointly capture the relationships among modalities spanning from chromatin architecture to transcription and translation. In this seminar, I will discuss experimental and computational methods developed for large-scale single-cell analysis, including inference and visualization of developmental trajectories, creation of cell atlases, and identification of cell-cell interactions. I will also highlight new multimodal profiling technologies and machine learning approaches from our laboratory for exploring gene expression programs and their dynamic regulation across diverse biological systems.

Guest talk by Christopher Gies (UOL)

https://uol.de/quantentheorie

14:00 - upload your data to DARE with Johannes

17:00 - Christmas party - more information TBA

We will be on an iRTG winter break and have our first seminar in 2026 on January 15th

Talks by Nav07 (Jesu) & Nav02 (Annika)

Chair: Jonathan